Santo Spirito in Saxia is one of the most important places of the historical-artistic heritage in Rome. Originally built on the command of the Saxon king to host his people during their pilgrimage Rome, the structure includes the famous Sixtine Wards, realized by some of the most prominent XVI century artists. They need to be restored, being a challenging task in the light of the high monumental value of the complex. the project documentation, made available by the Hospital Administration, owning the building, a preliminary study was conducted to define technical criticalities management strategies and project coordination, by virtue of the historical-monumental character of the compound. The works regard the restoration of the artworks and structures, along with the reroofing of the edifice; the design proposes also the realization of an underground historical-educational path including the archaeological digs of Villa Agrippina. By means of a multidisciplinary operational approach to choose the best technical-economic option, the project rationalizes plants and technologies, for a respectful renovation of artworks without disturbing the regular activities of the compound, with particular attention to hospital tasks.