In the Roman archaeological and monumental context, the Sepulchra Scipionum, along Via Appia Antica, has a peculiar relevance due to its symbolic picturesque value; besides the events which have marked its future over time along with the predatory interventions and the non-coordinated restorations, that jeopardized the knowledge and conservation of the place, increased the peculiarity of this archaeological site. During the conservative restoration, any criticality in interpretation was solved through an accurate series of research and analysis, that revealed a complex structure resulting from prior interventions, as well as some new information and hidden elements. The underground part consisted of a mixture of volumes, cubbies, enclosed spaces, breaches, recovered masonry and industrial metallic structures. The prevailing part of the works concerned the structural consolidation and monumental renovation of the site; in this regard, the areas of intervention were functionally divided into sectors called Calcara, Emiliana and Colombario. The main intervention typologies involved both the decaying sizable metallic structure at sight, realized during the restoring process in the XX century, and the secondary structures, hidden and not, as well as the masonry systems and all the elements involving archaeological aspects i.e. sarcophaguses, gravestone elements, Vatican’s copies. Furthermore, a study for a museum complex was carried out, with an outdoor area for the renovation and requalification of the location. The complexity of the program implied the coordination with the Municipality and the Superintendence of the Cultural Heritage, along with an advanced approach towards the historical knowledge.